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safety and effectiveness in these children have not been confirmed.PREGNANCY and BREAST-FEEDING: Metformin has been shown to cause harm to the fetus.
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Metformin may rarely be habit forming. Metformin should be avoided in patients with a history of opiate addiction or hypersensitivity to opiate medications.
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This may not be a complete list of all interactions that may occur. Ask your health care provider if Metformin may interact with other medicines that you take.
Metformin is well absorbed orally with an absolute bioavailability of 75%. Metformin has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Intramuscular (i.m.) Metformin increases gastric pH during anaesthesia similar to famotidine.
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For Metformin, the following should be considered:The suitability of Metformin suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated.
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Ask your pharmacist if you have questions about which medicines may cause drowsiness.Metformin may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect.
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